Neuronal®

Rapidly regenerates the damaged nerves

Neuronal®

Rapidly regenerates the damaged nerves

Neuronal® contains NCFR-6, a unique combination of nucleotides and vitamins which affects the natural process of regeneration of the damaged nerves due to pain conditions connected with the spine column.

The combination of active substances in the product Neuronal® is carefully chosen on the basis of positive results of scientific research.

Active components which can be found in the dietary supplement Neuronal® have an effect on the natural process of regeneration of the damaged nerves due to pain conditions connected with spine column such as:

  • neck pain
  • painful syndrome in the lumbar region
  • painful syndrome in the region of shoulders and arms
  • lumbago or a painful syndrome in the lower pars of the back
  • sciatica
  • compression of the roots of spinal nerves
  • various radiculopathies
  • discus hernia (before or after the operation) with the resulting neuralgias and polyneuropathies

NEURONAL® contains NCFR-6, a unique combination of the following nucleotides and vitamins:

  • Nucleotide (UMP) – 50 mg
  • Niacin – 20 mg
  • Vitamin B6 – 4.2 mg
  • Vitamin B1 – 3 mg
  • Folate – 400 µg
  • Vitamin B12 – 9 µg

Does not contain salt, gluten, yeast, soy or dairy products. The product does not contain preservatives. Convenient for vegans and vegetarians.

Dosage:

  • one capsule a day with a little water
  • it is recommended that the capsules should be taken for at least one month

The users will feel the benefits of using Neuronal® capsules in a few days’ time.

If need be, the usage of Neuronal® capsules can be repeated as long as the patients do not feel the improvement.

Neuronal® is a natural and safe product that can be used as long as it is necessary.

Nucleotides

Numerous researches have showed that the usage of nucleotides is efficient in the reduction of pain intensity in patients with diabetic and compressive neuropathies, and that they have a significant role in the neuroregeneration.

Nucleotides are monomer structure units consisting of a sugar group, connected with one or more phosphate groups and nitrogenous base, which can be cytosine, adenine, guanine, thymine or uracil.

Nucleotides

Numerous researches have showed that the usage of nucleotides is efficient in the reduction of pain intensity in patients with diabetic and compressive neuropathies, and that they have a significant role in the neuroregeneration.

Nucleotides are monomer structure units consisting of a sugar group, connected with one or more phosphate groups and nitrogenous base, which can be cytosine, adenine, guanine, thymine or uracil.

Uridine-monophosphate

Uridine-monophosphate (UMP) is a nucleotide which is important for the synthesis of ribonucleic acid (RNA). It is a precursor of thymidine which is the integral part of DNA. UMP is resorbed through the intestinal tract by the eased diffusion and it goes through hematoencephalic barrier.

The role of UMP in neurons:

  • participates in RNA synthesis
  • participates in the synthesis of phosphatidylcholine, i.e. phospholipids necessary for the creation of cellular membranes.
  • regenerates dendrites which imitate the synaptic functions
  • stimulates the proliferation of Schwann cells and thus participates in the formation of myelin
  • induces cell growth and neuron differentiation and thus achieves the neuroprotective activity
  • extracellular UMP inter-reacts with nucleotide receptors of Schwann cells and activates the molecular apparatus that induces the changes in the cytoskeleton in case of neuropathy.
  • pharmacological researches point out that UMP accelerates and helps the neuromuscular regeneration and inhibits the transmitters for conducting the pain to the spinal cord
  • belongs to the nootropic substances (goes through the hematoencephalic barrier) and has positive effect on cognitive functions
Folic acid (vitamin B9)

Folic acid is one of the most important vitamins for human health.

The role of folic acid in neurons:

  • a significant number of its derivatives, known as folates, are the cofactors of numerous enzymes that participate in the synthesis of amino-acids, i.e. proteins
  • participates in the biosynthesis of nucleotides, so it has a key role in the synthesis of DNA and RNY, and on the other hand, defines the division of cells
  • affects the activity of genes during the regeneration of nerve cells

 

Vitamin B12 (cobalamin)

Vitamin B12 is necessary for the production of myelin.
It plays a key role in two important biochemical reactions in the human organism:

  • formation of methionine through the process of homocysteine methilation
  • formation of tetrahydrofolate is necessary for the synthesis of purine and pyrimidine, and thus for DNA and RNY as well, as the secondary products of this reaction

Transformation of L-methylmalonyl coenzyme A into succinyl A coenzyme is of great importance for the formation of the myelin sheath.

Stiffness, numbness and the loss of sensibility are the symptoms that are manifested in peripheral neuropathy caused by the deficiency of vitamin B12.

According to statistical data, between 5% and 20% of adult population suffer from vitaminB12 deficiency, and more than 40% have shown a low level of vitamin B12 in the plasma.

Vitamin B6 (pyridoxine)

After the absorption, vitamin B6 is transformed into pyridoxal pyrophosphate which is an important cofactor of numerous metabolic reactions of amino acids, glucose and lipids.

In adults, the neuropathy caused due to the deficiency of vitamin B6 starts with numbness, paresthesia or burning pains in the feet, and then, with ascendant propagation, takes the legs and arms.

Neurological examinations point to the presence of polyneuropathy with the weakened distal sensitivity, weakened tendon reflexes, ataxia and mild distal weakness.

Even though vitamin B6 can be found in quite a lot of food, after its treatment, it loses even up to 70% of this vitamin.

On the other hand, vitamin B6 cannot be synthesized, which is why the intake of food and dietary supplements rich in this vitamin are of essential importance

Vitamin B1 (thiamine)

Vitamin B1 is present in most of the plat and animal tissues. It is resorbed in the intestines by a passive diffusion and active transport, and then it is quickly transformed into thyamine diphosphate (TDP) which is physiologically active in the form of vitamin B1.

TDP serves as the main cofactor in oxidation processes (cellular breathing), in the production of adenosine triphosphate (ATP), in the synthesis of glutamate and Y-aminoadipic acids and as a good support in the formation of the myelin sheath.

The deficiency of thiamine leads to the neuropathy known as beriberi which was the first described deficiency syndrome in people.

Fatigue, nervousness and muscular spasms can occur within a few days or weeks as a result of the deficiency of this vitamin in the diet.

Clinical features of the thiamine deficiency start with a distal loss of sensitivity, burning pain paresthesia and muscular weakness in legs and feet.

Vitamin B3 (niacin)

Vitamin B3 is resorbed in the intestines by a simple diffusion.  Niacin and its derivative nicotinamide (contained in NAD and NADP) are important for metabolism of carbohydrates, fats, proteins as well as for the transfer of intra-cellular signals and the reparation of DNY in cells.

The deficiency of niacin in a diet may cause nausea, skin and labial lesions, anaemia, headache and fatigue.

Pellagra is a disease caused by the deficiency of vitamin B3, and its three classic clinical manifestations are dementia, dermatitis and diarrhoea.

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