Dianerv Max

Composition:

Dianerv Max has superior characteristics thanks to innovative manufacturing technologies:

Efficacy confirmed by clinical studies:

Bertolloto F et al. – After 4 months of therapy, electroneurographic parameters and pain perception were significantly improved in patients with symptoms of diabetic neuropathy using SOD+ALA. The greatest improvement is achieved in sensory nerve conduction.

Anders A F Sima et al. – Pain reduction with ALC is inversely proportional to the duration of Diabetes mellitus

Effects:

Diabetic peripheral neuropathy (DPN) → the presence of symptoms and/or signs of peripheral nerve damage in patients with diabetes, in whom other possible causes of neuropathy have been excluded. DPN first manifests on the feet in the form of tingling, prickling, burning, “socks and gloves” sensitivity disorders, allodynia, hyperalgesia, vibratory perception disorders… or also reduced vision and hearing with dizziness and tinnitus.

Oxidative stress – diabetic neuropathy is based on a glucose metabolic disorder that leads to excessive oxidative stress (increased production of harmful free radicals), which results in damage to the endothelium of blood vessels and ischemic changes in peripheral nerves.

Antioxidants in DPN therapy → powerful molecules that prevent the formation of free radicals and prevent the initiation of oxidative stress that causes cell damage. They are divided into:

• Primary antioxidants (superoxide dismutase) → prevents the formation of new free radicals;
• Secondary antioxidants (alphalipoic acid) → neutralizes free radicals created during oxidative stress (cleansers).

Superoxide dismutase (SOD) → neutralization of superoxide radicals O2-.

• vasculoprotective,
• anti-inflammatory (reduces the production of IL-6 and TNF)
• neuroprotective (improves cognition).

GliSODin® complex → patented biopolymer that protects SOD during its passage through the stomach, ensuring stability and greater resorption of SOD, as well as greater efficiency compared to free SOD

Alpha lipoic acid (ALA) → secondary antioxidant, “cleaner” of free radicals

Effects:

• improves blood flow in the vasa nervorum
• reduces pain
• increases the nerve conduction velocity
• improves glucose utilization
• potentiates the renewal of endogenous antioxidants (vitamin E, vitamin C, glutathione)

Physio Release® production technology enables the superior characteristics of ALA: increased bioavailability and efficiency, with a favorable safety profile (stable molecules without interactions); application independent of the intake of food, minerals and milk products.

Compreezer® technology → ensures preservation of the functional characteristics of temperature-sensitive ingredients (such as ALA), increases product quality and efficiency.

Acetyl L-carnitine (ALC) in DPN therapy → an essential role in the metabolism of fatty acids in the mitochondria, where they undergo the process of β-oxidation, whose product is energy in the form of ATP.

Effects:

• increases energy metabolism and self-repair capabilities of damaged nerves
• reduces oxidative stress
• reduces pain and improves vibratory perception
• significantly improves the sensory nerve conduction velocity
• participates in the production of the key brain transmitter, acetyl choline, as well as in the synthesis of membrane lipids and proteins → improves cognitive functions and reduces the feeling of mental and physical fatigue

Vitamin B12 in DPN therapy → participates in the synthesis and regeneration of myelin; participates in the synthesis of neurotransmitters and improves nerve conduction; improves somatosensory symptoms, such as pain and paresthesia.

Vitamin B12 deficiency is very common in patients with DM and can cause neurological manifestations, such as painful peripheral and autonomic neuropathies.

Vitamin B12 deficiency is associated with the use of metformin, which inhibits the intrinsic factor and thus reduces its absorption. Therefore, in patients with DPN who use metformin, daily supplementation of vit B12 in a dose of 2.4 mcg is necessary.