OsteoMAX®

Composition

Indications – to whom we recommend:

• Patients with reduced bone density (osteopenia and osteoporosis)
• Postmenopausal women
• Vitamin D, K2 and calcium deficiency
• After a fracture, as support for accelerated healing
• Support the immune system
• For patients with osteoporosis, as co-therapy in addition to basic treatment
  • Additional supplementation with calcium and vitamin D is recommended along with bisphosphonates
  • Additional calcium and vitamin D supplementation is recommended with Denosumab

Benefits:

• Use independent of meals
• They do not cause gastrointestinal adverse effects (gas, flatulence, constipation)
• Suitable for people with achlorhydria, inflammatory bowel disease and malabsorption, as well as those using H2 blockers and/or proton pump inhibitors
• They do not lead to the formation of renal calculi, but are used in the prevention and treatment of this condition
• The addition of vitamin K2 reduces the risk of osteoporosis and consequent fractures, as well as vascular calcifications

Favorable safety profile.

Efficacy confirmed by clinical studies.

MICROENCAPSULATED VITAMIN K2 ALL-TRANS MK-7 → The only patented vitamin K2 for combined use with minerals, of high purity, absorption, stability and efficiency.
Double encapsulation allows isolation and protection of K2 MK-7 from direct contact with alkaline salts, such as calcium and magnesium.
In combination with calcium, K2Vital®Delta shows superior stability, compared to unprotected K2 MK-7.

Osteoporosis

Osteoporosis is a systemic disease of bone tissue characterized by low bone strength (mass), changes in microarchitecture and loss of bone tissue, which increases bone fragility and susceptibility to fractures.

Clinical features

• Clinically silent disease (Painless disease, “silent bone stealer”)
• Pain after fracture – vertebral body, neck of femur, forearm, other long bones
• Fractures – spontaneous and after minor trauma
• Deformities of body parts after a fracture, reduction of body height
• Nerve compression
• Bleeding due to blood vessels erosion

Vitamin D

Regulates calcium metabolism; promotes its resorption from the digestive tract and incorporation into bone and teeth – ensures normal bone mineralization.

A typical daily diet provides ∼ 3mcg per day (120IU).

Serum 25(OH)D concentration is the best indicator of vitamin D status.

Vitamin D hypovitaminosis → plasma 25 hydroxycholecalciferol <25 nmol/l (10 ng/ml).

Vitamin D recommendations depending on age:

Calcium

Calcium is an essential element required for normal bone metabolism
Calcium supplements are advised when food intake is < 800 mg/24h.

Recommendations for daily intake:

*For infants 0 to 6 months and 6 to 12 months, these are Adequate Intakes (AI)

 Calcium citrate, benefits:

• More favorable safety profile at the level of the digestive tract (gas, bloating, constipation)
• Absorption independent of food intake
• Useful in people with achlorhydria, inflammatory bowel disease and malabsorption, as well as those using H2 blockers and/or proton pump inhibitors
• It does not lead to the formation of renal calculi, but is used in the prevention and treatment of this condition

Vitamin D + calcium

• a combination of choices for the prevention or treatment of osteoporosis (José Manuel Quesada Gómez et al: Calcium citrate and vitamin D in the treatment of osteoporosis; Clin Drug Investig. 2011;31(5):285-98)
• reduces the risk of fractures; total by 15%, and hip fracture by 30% (C. M. Weaver et al: Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation Osteoporosis Int (2016) 27:367-376.)

Vitamin K2

Liposoluble vitamin, forms:

• K1 (phylloquinone) – role in the blood coagulation process
• K2 (menaquinone MK 4 to MK 10, of which the MK-7 form has the highest bioavailability) – roles:
  1. Calcium deposition in the bones
  2. Prevention of calcium deposition in arteries, soft tissues and organs

The usual daily dose of vitamin K2-7 in patients with osteoporosis is 45 mcg/day.

Vitamin K2 is an essential cofactor for the activation of the enzyme Y-carboxylase, thus participating in the carboxylation and activation of vitamin K-dependent proteins in bones (osteocalcin) and smooth muscles of the arterial wall (matrix GLA protein). Thus, vitamin K2 reduces the risk of osteoporosis and consequent fractures, as well as vascular calcificationscalcifications.

Vitamin K2-MK7 intake at a dose of 45 mcg daily reduces mortality by 50% in CV events associated with arterial calcification and 25% in overall CV mortality. (Johanna M. Geleijnse et al Dietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease: The Rotterdam Study J Nutr 2004; 134:3100-5. European Journal of Biotechnology and Bioscience 2014; 2 (6): 25-29.)

VITAMIN D + CALCIUM + VITAMIN K2 → significant improvement of bone density and lower incidence of fractures (Fazeel ZA et al: Efficacy of Vitamin K as a supplement in Osteoporosis. European Journal of Biotechnology and Bioscience 2014; 2 (6): 25-29.)

Method of use (dosage):

Adults: 1 sachet per day. Dissolve the contents of the sachet in a glass of water, mix well and drink immediately.

Packaging:

30 sachets with a pleasant orange taste