Cerebronal

For conditions accompanied by cognitive deficit

Cerebronal

Cerebronal is a patented complex formulation which is indicated for use in conditions accompanied by cognitive deficit.
Uridine monophosphate (UMP), choline and docosahexaenoic acid (DHA), contained in Cerebronal, are key elements for the creation of functional synapses, as confirmed by clinical studies.

Composition:

Blue Blister

Active components
2 capsules (daily dose)
Choline bitartrate-choline
392 mg
161.24 mg
Acetyl-L-carnitine-hydrochloride
210 mg
Nucleotides
200 mg
Uridine 5 monophosphate
200 mg
Cytidine monophosphate
200 mg
Nucleotides
30 mg
Guanine monophosphate
30 mg
Adenine monophosphate
30 mg
Uridine monophosphate
30 mg
Cytidine monophosphate
30 mg
Nucleosides
30 mg
Other nucleotides
30 mg

Pink Blister

Active components
1 capsule (daily dose)
DHA
500 mg
250.0 mg
Astaxanthin
3 mg
Pantothenic acid
5 mg
Niacin
5 mg
Thiamin (Vitamin B1)
2 mg
Vitamin B6
2 mg
Riboflavin (Vitamin B2)
2 mg
Folic acid
400 μg
Vitamin B12
10 μg
Vitamin D
10 μg

Cerebronal is recommended

  • for people with impaired mental functioning, ranging from mild cognitive decline (impaired thinking, memory, perception, learning, attention, perception of the environment, logical reasoning) to dementia

Cerebronal has the following effects:

  • It promotes regeneration of the damaged nerve
  • It encourages the creation of functional synapses and the transmission of stimuli (synaptic transmission).
  • It increases the density of dendritic processes and encourages the formation of new synapses
  • Improves cognitive functions (thinking, memory, attention, perception…)
  • It has an anti-inflammatory, antioxidant and neuroprotective effect
  • It improves the energy balance of nerve cells
  • It reduces the use of other therapeutic options
  • It has a favorable safety profile
  • Clinical efficacy has been confirmed by studies

Method of use:

Adults: 3 capsules per day; take 1 capsule in the pink package and 2 capsules in the blue package, once a day, with a little liquid.

Packaging

45 capsules

Nucleotides

Nucleotides are monomeric structural units composed of a sugar group, attached to one or more phosphate groups, and a nitrogenous base, which can be cytosine, adenine, guanine, thymine or uracil.

Uridine monophosphate

Uridine monophosphate (UMP) is a nucleotide that is important for ribonucleic acid (RNA) synthesis. UMP is resorbed in the intestinal tract via facilitated diffusion and crosses the blood-brain barrier.

Role of UMP in neurons:

  • It participates in the synthesis of RNA
  • It participates in the synthesis of phosphatidylcholine necessary for the formation of biological membranes
  • It is a precursor for the synthesis of the neurotransmitter acetylcholine, which is deficient in dementia
  • It promotes neurogenesis, neuronal differentiation and neuroregeneration
  • It stimulates the proliferation, migration and activity of Schwann cells, as well as the secretion of nerve growth factor (NGF) and supports the formation of the myelin sheath, necessary for the transmission of stimuli.
  • It encourages the creation of functional synapses and the transmission of stimuli (synaptic transmission).
  • It affects the reduction of the concentration of fatty acids, which are precursors of scar formation (and which hinders nerve regeneration)
  • It has a positive effect on cognitive functions

Choline (vitamin B4)

Choline is a hydrophilic essential nutrient. It is produced by the liver from amino acids that we ingest by way of foods of animal origin (beef and pork, chicken, fish, dairy products, eggs).

Choline preserves the health of the nervous system, improves cognitive functions, and is also important for the proper functioning of the liver and muscles, as well as the conversion of fat into energy.

Insufficient amounts of choline lead to the deposition of fat in the liver and the consequent obesity.

The role of choline in neurons:

  • It is a building block of cell membranes – phosphatidyl choline and the neurotransmitter acetylcholine
  • Improves synaptic transmission – increases the number and density of dopamine and acetylcholine receptors and the fluidity of the brain membrane
  • Improves cognitive functions (thinking, memory, attention, perception…)

Docosahexaenoic acid (DHA)

DHA is an omega-3 fatty acid, which can be synthesized from alpha-linoleic acid or obtained directly from breast milk, algae oil or fish oil. The main sources are fish and seafood, followed by poultry and eggs, then milk and dairy products.

Role of DHA in neurons:

  • DHA is a structural component of the cerebral cortex in humans, and is deficient in patients with dementia
  • DHA has a positive effect on preserving the structure of brain cells and reduces cell death of neurons
  • It is a powerful second messenger that activates proteins and enzymes necessary for synaptogenesis
  • It has a strong anti-inflammatory and neuroprotective effect
  • Improves cognitive functions

Acetyl L Carnitine (ALC)

Acetyl L-carnitine (ALC) is an ester of L-carnitine, which is formed by the acetylation of carnitine in the mitochondria. It has similar functions in the body as carnitine, but it is more quickly and efficiently absorbed and transported by the bloodstream, because it passes through the cell membrane more easily.

Role of ALC in neurons:

  • It enables the transport of long-chain fatty acids into the mitochondria and energy production
  • Improving the cognitive function of the brain, because it participates in the production of the key brain transmitter, acetylcholine
  • It promotes the regeneration of neurons
  • It donates an acetyl group for numerous biochemical reactions

Astaxanthin

Astaxanthin belongs to the group of carotenoids – a red pigment produced by synthesis in microalgae.
Humans and animals cannot synthesize astaxanthin, but take it in through food (salmon, sea crab – krill, quail, shrimp, lobster).

Proven stronger anti-oxidant capabilities of Astaxanthin

Studies have shown stronger anti-oxidant capabilities in relation to familiar anti-oxidants:

A study from 2007 that analyzed known antioxidants and their anti-oxidative capacity has shown that Astaxanthin is 6000 times stronger than Vitamin C, 800 times stronger than Coenzyme Q10, 550 times stronger than green tea Catechins and 75 times stronger than Alphaliponic acid.

Natural astaxanthin is the strongest known antioxidant.

Role of astaxanthin in neurons:

  • Astaxanthin significantly improves cognitive functions
  • It has a positive effect on atherosclerosis
  • It has a strong anti-inflammatory effect

Folic acid (vitamin B9)

Folic acid is one of the most important vitamins for human health.
Derivatives of folic acid, folates, are cofactors of many enzymes involved in the synthesis of amino acids, nucleotides, DNA and RNA.

Role of folic acid in neurons:

  • It participates in the biosynthesis of nucleotides, so it has a key role in the synthesis of DNA and RNA
  • It promotes neuro-regeneration
  • It stimulates the proliferation, migration and activity of Schwann cells, as well as the secretion of nerve growth factor (NGF) and supports the formation of the myelin sheath, necessary for the transmission of stimuli.

Vitamin B12 (cyanocobalamin)

Vitamin B12 is a water-soluble vitamin, originating from foods of animal origin – liver, kidneys, milk, meat, eggs, cheese, fish and shellfish.

Role of vitamin B12 in neurons:

  • Production of genetic material RNA and DNA
  • It is essential for the normal functioning of nerve cells and the brain:
  • It has an analgesic effect
  • It participates in the synthesis of the myelin sheath of the axon
  • Participates in the synthesis of neurotransmitters (molecules that transmit electrical signals between neurons and target cells – other neurons, muscle, gland cells

Deficiency of vitamin B12 causes anemia, neuropathy (stiffness, tingling and loss of sensation) and dementia.

Vitamin B1 (thiamine)

Vitamin B1 is present in most plant and animal tissues. It is absorbed in the small intestine by passive diffusion and active transport, and then quickly transformed into thiamine diphosphate (TDP), which is the physiologically active form of vitamin B1.
TDP serves as a basic cofactor in the processes of oxidation (cellular respiration), in the production of adenosine triphosphate (ATP), in the synthesis of glutamate and Y-aminoadipic acid and provides good support in the creation of the myelin sheath.

Role of vitamin B1 in neurons:

  • Suppresses nociceptive and neuropathic pain
  • Improves energy processes in nerve tissue (ATP synthesis), reduces oxidative stress
  • It participates in axonal transport and synaptic transmission

Deficiency of vitamin B1 leads to neuropathy known as beri-beri, which is most often manifested by pain in the extremities and a change in skin color.
Fatigue, irritability and muscle cramps can appear within days or weeks as a result of a lack of this vitamin in the diet.

Vitamin B2 (riboflavin)

Vitamin B2 is a water-soluble vitamin, present in small amounts in almost all foods of vegetable and animal origin, therefore a balanced diet usually provides sufficient amounts of this important vitamin. It is important for the metabolism of carbohydrates, fats and proteins. It is also important for the proper formation of erythrocytes. It participates in the production of antibodies, and it is also important for the processes of growth and cellular respiration.

A long-term lack of riboflavin in the body is called ariboflavinosis and occurs in people with improper nutrition. The main manifestations are: swelling, redness and cracking of the skin on the edges of the lips, then swelling and cracks on the tongue, redness and swelling on the eyelids and conjunctivae. Hypovitaminosis has a negative effect on growth and reproduction, digestion, the creation of antibodies and the general defense ability of the organism.

Vitamin B3 (niacin)

Vitamin B3 is resorbed in the intestines by simple diffusion. Niacin and its derivative nicotinamide (included in the composition of NAD and NADP) are important for the metabolism of carbohydrates, fats, proteins, as well as for the transmission of intracellular signals and DNA repair in cells.

Role of vitamin B3 in neurons:

  • It enables the normal functioning of the nervous system and the maintenance of normal metabolism associated with the delivery of the necessary energy to the nervous tissue

A lack of niacin in the diet can cause nausea, skin and labial lesions, anemia, headache and fatigue. Deficiency of vitamin B3 leads to a disease known as pellagra, which is manifested by the classic clinical triad: dementia, dermatitis and diarrhea.

Vitamin B5 (pantothenic acid)

Vitamin B5 is a water-soluble vitamin, widely distributed in food of plant and animal origin. In addition, it is also produced by the human intestinal flora.
It is an integral part of coenzyme A, which is necessary for the metabolic process of acetylation of carbohydrates, fats and proteins. It is important for the process of beta-oxidation and synthesis of fatty acids and sugar metabolism. Vitamin B5, an anti-stress vitamin, is of great importance for the development of the central nervous system.

Deficiency leads to neuromuscular disorders, which are manifested by fatigue, depression, loss of appetite, cramps, indigestion and insomnia.

Vitamin B6 (pyridoxine)

Vitamin B6 is an essential vitamin, which cannot be synthesized by the body, but must be taken in through food and nutritional supplements.
After absorption, vitamin B6 is transformed into pyridoxal pyrophosphate, which is an important cofactor in multiple metabolic reactions of amino acids, glucose and lipids.

Role of vitamin B6 in neurons:

  • Increases the activity of analgesic neurotransmitters (noradrenaline, serotonin)
  • It improves protein synthesis, which are the structural elements of nerve fibers, fat synthesis and energy metabolism
  • It participates in the synthesis of key neurotransmitters

In adults, neuropathy caused by a lack of vitamin B6 begins with tingling, paresthesias or burning pains in the feet, and then involves the legs and arms by ascending propagation.

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