Biologically active 4th generation folic acid


DAFNEFOL400 is a 4th generation biologically active folic acid in the form of orange-flavored orodispersible tablets that is highly soluble, stable, and whose metabolism is not affected by the functional polymorphism of the MTHFR and DHFR genes.


  • Folic acid deficiency and in the treatment of hyperhomocysteinemia
  • In preconception and pregnancy:
    • prevention of neural tube defects and other malformations
    • cases of MTHFR gene mutation
    • folic acid deficiency
    • reduced DNA methylation
    • anemia


Folic acid (Vitamin B9) is a water-soluble B-complex Vitamin essential for numerous health functions in our body. It is mainly found in fruits and vegetables, especially dark, leafy greens and beans. Since the human body cannot produce folic acid, it is necessary to get it from food or take dietary supplements.

Folic acid stimulates tissue growth in women during pregnancy, plays an important part in the cell division process, it helps the normal synthesizing of amino acids and normal blood formation. It also plays an important role in lowering the circulating homocysteine concentrations, a toxic molecule harmful to the body, which is considered a potential biomarker for some chronic degenerative diseases.

Given that folate from dietary sources and folic acid are not biologically active, first they have to be converted into metabolically active 5-methyltetrahydrofolate (5-MTHF) through a multi-step process in which the enzyme methylenetetrahydrofolate reductase (MTHFR) plays a key role. Due to the polymorphism of the MTHFR gene, some individuals are unable to convert folic acid into a metabolically active form, which is a risk factor for the onset and development of the disease.

The percentage of respondents with polymorphism of the MTHFR C677T gene is 62%.
*Heterozygote 45%, Homozygote 17%

Polymorphism of the MTHFR is a risk factor associated with:

  • Hyperhomocysteinemia
  • Neural tube defects in pregnancy
  • Chronic diseases due to folate deficiency
  • Decreased levels of DNA methylation

This condition can also lead to the accumulation of unmetabolized folic acid (UMFA), which has a toxic effect on the body.

DAFNEFOL400 contains Quatrefolic®, 4th generation folic acid and the most biologically active form available.

Quatrefolic® is glucosamine (6S)-5-methyltetrahydrofolate salt and is structurally analogous to the reduced and active form of folic acid which:

  • does not require biotransformation by the enzymes DHFR, THFR and MTHFR to become active,
  • is not affected by functional polymorphisms in the MTHFR and DHFR2 genes
  • does not lead to the accumulation of the UMFA in the blood

DAFNEFOL400 component Quatrefolic® is a patented ingredient that provides greater stability and higher water-solubility.

It is an excellent option for vegetarians.


Folic acid (Quatrefolic®, 5-MTHF-glucosamine) 400mcg

Route of administration:

1 tablet a day, to be dissolved under the tongue.


Dafnefol400 contains 90 orange-flavored orodispersible tablets that do not contain glutein or lactose.

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Vemax011 Pharma doo representative office Northern Macedonia - Dane Krapcev 13, Skopje

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+381 (0)69 801 47 87


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