For the symptomatic treatment of osteoarthritis in the knee


  • Na-hyaluronate 30mg/2ml

Sterile, viscoelastic solution for intra-articular use indicated for the symptomatic treatment of osteoarthritis in the knee.


It consists of linear chains of sodium hyaluronate, with a medium molecular weight of (2.4 x 106 Dalton), obtained from Streptococcus bacteria and purified by fermentation.

This molecular weight promotes strong binding to fibroblast receptors, activation of a large number of receptors and stimulation of endogenous biosynthesis of hyaluronic acid.

Method of use:

Hyalmax is applied to the affected joint once a week for three consecutive weeks.
Do not exceed one cycle of treatment for any single joint in a 6-month period.
The product is used exclusively as an intra-articular injection.

Hyaluronic acid

Hyaluronic acid is a typical glycosaminoglycan (GAG), the only one that exists free, not bound to proteins.

Sodium hyaluronate is made of disaccharide units consisting of sodium glucuronate and N-acetylglucosamine. It is present in all tissues, is highly biocompatible and forms the main component of synovial fluid, where it is found in high concentration.

Mechanism of action of sodium hyaluronate:
Viscosupplementation enables lubrication and shock absorption
Visco-induction Establishing joint homeostasis by inducing endogenous production of hyaluronic acid lasts a long time after the injection itself

The most important effects of sodium hyaluronate:

  • Lubricant effect
  • Anti-inflammatory effect
  • Analgesic effect
  • Chondroprotective effect
  • Endogenous synthesis of hyaluronic acid

Clinical studies have proven that the intra-articular application of sodium hyaluronate provides a reduction in the simultaneous use of analgesics by up to 50%, and postpones the need for surgical implantation of a prosthesis.

Instructions for use (pdf 3.91 MB)

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Vemax011 Pharma doo representative office Northern Macedonia - Dane Krapcev 13, Skopje

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